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When 5-fu is given within 24 hours prior to methotrexate, the cytotoxicity of methotrexate is decreased.

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muromonab-cd3 minor the concomitant use of muromonab and methotrexate may cause additive immunosuppression.

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decreased elimination of methotrexate.

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the safety profile of concomitant use of potentially hepatotoxic drugs, such as methotrexate, and riluzole has not been established.

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assessment of hematologic, hepatic, renal, and pulmonary function should be made by history, physical examination, and laboratory tests before beginning, periodically during, and before reinstituting methotrexate therapy.

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onco docs say it normal and a side effect of the methotrexate.

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