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64 uricosurics increase the renal excretion of oxypurinol, thus offsetting to some degree the urate-lowering effect of allopurinol.

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oxipurinol, however, has a longer plasma half-life approximately 15 hours and therefore effective xanthine oxidase inhibition is maintained over a 24-hour period with single daily doses of zyloprim allopurinol .

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