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Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine and does not inhibit monoamine oxidase or the reuptake of serotonin.

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at least 14 days should elapse between discontinuation of an maoi and initiation of bupropion.

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the pharmacokinetics of bupropion and its active metabolites were not statistically significantly different in patients with mild to moderate cirrhosis when compared to healthy volunteers, although more variability was observed between individual patients.

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psychotherapy and, if necessary, antidepressant medication such as bupropion wellbutrin and generics , citalopram celexa and generics , and fluoxetine prozac and generics , can often help.


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