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Prozac sarafem can be used to reduce the observable symptoms of premenstrual dysphoric instability, trouble, consisting of changes in mood, frustration, and breast pain.

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Some clinical data suggests a possible pharmacodynamic and/or pharmacokinetic interaction between SSRIs and antipsychoticsElevation of blood levels of haloperidol and clozapine has been observed in patients receiving concomitant fluoxetinesee CONTRAINDICATIONS

This is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist.

Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy.

Systematic evaluation of SARAFEM has shown that its efficacy in PMDD is maintained for periods of up to 6 months at a dose of 20 mg/day given continuously and up to 3 months at a dose of 20 mg/day given intermittentlysee Clinical StudiesPatients should be periodically re-assessed to determine the need for continued treatment.

If concomitant use of SARAFEM with other serotonergic drugsthat istriptanstricyclic antidepressantsfentanyllithiumtramadolbuspironetryptophan and StJohn’s Wort is clinically warrantedpatients should be made aware of a potential increased risk for serotonin syndromeparticularly during treatment initiation and dose increases.

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