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Careful monitoring of infusion pump function and inspection of catheter tubing for obstruction or dislodgement is recommended to reduce the risk of accidental abrupt withdrawal of epidural clonidine.

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systolic and diastolic bp were analysed separately using 2-way 3 3 repeated- measures anovas, with drug treatment placebo, clonidine or guanfacine and time pre-drug, post-drug or post-testing as within- subject factors.

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the plasma level of clonidine hydrochloride peaks in approximately 3 to 5 hours and the plasma half-life ranges from 12 to 16 hours.

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clonidine therapy should not be abruptly discontinued because your child may experience a rapid increase in blood pressure and overactivity of the central nervous system, which includes increased heart rate, palpitations, tremors, anxiety, agitation, insomnia, and sweating.

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