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Proceeding from the visible surface towards the surface attached to the skin, are four layers 1 a backing layer of pigmented polyester film; 2 a drug reservoir of clonidine, mineral oil, polyisobutylene, and colloidal silicon dioxide; 3 a microporous polypropylene membrane that controls the rate of delivery of clonidine from the system to the skin surface; 4 an adhesive formulation of clonidine, mineral oil, polyisobutylene, and colloidal silicon dioxide.

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epidural administration duraclon is indicated in combination with opiates for the treatment of severe pain in patients with cancer not adequately relieved by opioid analgesics alone restrict use to pediatric patients with severe, intractable pain from malignancy that is unresponsive to epidural or spinal opiates or to other, more conventional analgesic techniques more likely to be effective in patients with neuropathic pain than in those with somatic or visceral pain safety and effectiveness of epidural administration in this limited indication and clinical population have been established in patients old enough to tolerate placement and management of an epidural catheter; these conclusions are based on evidence from adequate and well-controlled studies in adults and through experience with the use of clonidine in the pediatric age group for other indications.

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