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Proceeding from the visible surface towards the surface attached to the skin, are four layers 1 a backing layer of pigmented polyester film; 2 a drug reservoir of clonidine, mineral oil, polyisobutylene, and colloidal silicon dioxide; 3 a microporous polypropylene membrane that controls the rate of delivery of clonidine from the system to the skin surface; 4 an adhesive formulation of clonidine, mineral oil, polyisobutylene, and colloidal silicon dioxide.

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