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Due to widespread parasitological resistance and evidence of high rates of treatment failure with chloroquine, in 1993 malawi became the first country in africa to discontinue chloroquine use and adopted sulfadoxine-pyrimethamine for the treatment of uncomplicated malaria 12 .

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in clinical trials of rheumatoid arthritis patients, taro-etodolac has been used in combination with gold, d-penicillamine, chloroquine, corticosteroids and methotrexate.

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these reports of chloroquine-prophylaxis or treatment failures were substantiated by serial parasitologic and clinical observations of each infection and, when available, in-vitro confirmation of drug resistance.

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